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Relation Between Levels of Radiation and Frequencies of Cytogenetic Aberrations

Calvin L. Williams and Khursheed Alam

In toxicology, we study the relationships between doses and response where dose refers to the concentration of a damaging agent to which a subject is exposed and response is the observed effect on the subject following exposure. In this paper, we present a new model for the statistical analysis of dose-response data in cytogenetic dosimetry. In application, we consider the experimental data from Balasem and Ali(1991). Here the data consists of frequencies of binucleated cells divided into three categories, namely cells with zero, one and two or more number of micronuclei(MN), corresponding to ten different levels of radiation.

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